Reproduction Abstracts

In recent years, advances in molecular biology and reproductive engineering make generation of knockout (KO) animals possible. KO animals are useful and powerful tools for agriculture as well as biomedical research. Zinc finger nuclease (ZFN) and transcription activator-like effector nuclease (TALEN) genome editing technology enables site directed engineering of the genome. The aim of the present study was to ZFN and TALEN system could work on editing genome of cultured porcin...

Although GH receptor (GHR) gene deletion causes a hereditary dwarfism and also shows a longer lifespan, the fact was shown only in mice. Because it was difficult to generate knockout (KO) animals other than mice. Recently, the generation of KO animals became possible without difficulty due to advances in genome editing technologies such as transcription activator-like effector nuclease (TALEN). In the present study, we examined the effect of cRNA concentration microinjected cy...